8EV7

Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs

This is a non-PDB format compatible entry.

Summary for 8EV7

• Entry DOI: 10.2210/pdb8ev7/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total)
• Functional Keywords: kanamycin, antibiotic, aminoglycoside, 70s ribosome, inhibitor, trna, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4560660.35

Authors

Seely, S.M.,Gagnon, M.G. (deposition date: 2022-10-19, release date: 2023-08-09, Last modification date: 2023-11-15)

• Primary citation: Seely, S.M.,Parajuli, N.P.,De Tarafder, A.,Ge, X.,Sanyal, S.,Gagnon, M.G.; Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome.; Nat Commun, 14:4666-4666, 2023; PubMed: 37537169; DOI: 10.1038/s41467-023-40416-5

Experimental method

X-RAY DIFFRACTION (2.89 Å)