8ESV

Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab

8ESV の概要

• エントリーDOI: 10.2210/pdb8esv/pdb
• EMDBエントリー: 28580
• 分子名称: Disintegrin and metalloproteinase domain-containing protein 10, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CHOLESTEROL HEMISUCCINATE, ... (11 entities in total)
• 機能のキーワード: protease, metalloprotease, tetraspanin, sheddase, adhesion, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146651.73

構造登録者

Lipper, C.H.,Blacklow, S.C. (登録日: 2022-10-14, 公開日: 2023-06-14, 最終更新日: 2023-08-30)

• 主引用文献: Lipper, C.H.,Egan, E.D.,Gabriel, K.H.,Blacklow, S.C.; Structural basis for membrane-proximal proteolysis of substrates by ADAM10.; Cell, 186:3632-3641.e10, 2023; PubMed: 37516108; DOI: 10.1016/j.cell.2023.06.026

実験手法

ELECTRON MICROSCOPY (3.3 Å)