8EO6
Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution
Summary for 8EO6
Entry DOI | 10.2210/pdb8eo6/pdb |
Descriptor | LRA-5, ACYLATED CEFTAZIDIME (3 entities in total) |
Functional Keywords | beta-lactamase precursor, environmental resistome, soil metagenome, ceftazidime, oxyimino-cephalosporin, antimicrobial protein |
Biological source | uncultured soil bacterium |
Total number of polymer chains | 2 |
Total formula weight | 62893.80 |
Authors | Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (deposition date: 2022-10-02, release date: 2023-10-04) |
Primary citation | D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P. Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published, |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)