8EI4
Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide
Summary for 8EI4
Entry DOI | 10.2210/pdb8ei4/pdb |
Descriptor | NEDD4-like E3 ubiquitin-protein ligase WWP1, H302, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | e3 ligase, complex, stapled peptide, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 46766.64 |
Authors | Li, K.,Tokareva, O.S.,Thomson, T.M.,Verdine, G.L.,McGee, J.H. (deposition date: 2022-09-14, release date: 2023-10-25, Last modification date: 2023-11-15) |
Primary citation | Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H. Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14:6992-6992, 2023 Cited by PubMed: 37914719DOI: 10.1038/s41467-023-42395-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
Download full validation report