8EGU

Branched chain ketoacid dehydrogenase kinase complexes

Summary for 8EGU

• Entry DOI: 10.2210/pdb8egu/pdb
• Related: 8EGD 8EGQ
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid, ... (5 entities in total)
• Functional Keywords: branched-chain ketoacid dehydrogenase, branched-chain ketoacid dehydrogenase kinase, inhibitors, angiotensin receptor blocker, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 1
• Total formula weight: 45655.88

Authors

Liu, S. (deposition date: 2022-09-13, release date: 2023-03-08, Last modification date: 2023-10-25)

• Primary citation: Liu, S.,Kormos, B.L.,Knafels, J.D.,Sahasrabudhe, P.V.,Rosado, A.,Sommese, R.F.,Reyes, A.R.,Ward, J.,Roth Flach, R.J.,Wang, X.,Buzon, L.M.,Reese, M.R.,Bhattacharya, S.K.,Omoto, K.,Filipski, K.J.; Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.; J.Biol.Chem., 299:102959-102959, 2023; PubMed: 36717078; DOI: 10.1016/j.jbc.2023.102959

Experimental method

X-RAY DIFFRACTION (1.923 Å)