8EED

Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein

Summary for 8EED

• Entry DOI: 10.2210/pdb8eed/pdb
• Descriptor: Envelope protein E, rhMZ107-B antibody heavy chain, rhMZ107-B antibody light chain (3 entities in total)
• Functional Keywords: zikv, zikv-specific, cross-protomer epitopes, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013; More
• Total number of polymer chains: 12
• Total formula weight: 367231.47

Authors

Sankhala, R.S.,Joyce, M.G. (deposition date: 2022-09-07, release date: 2023-08-30)

• Primary citation: Sankhala, R.S.,Dussupt, V.,Donofrio, G.,Gromowski, G.D.,De La Barrera, R.A.,Larocca, R.A.,Mendez-Rivera, L.,Lee, A.,Choe, M.,Zaky, W.,Mantus, G.,Jensen, J.L.,Chen, W.H.,Gohain, N.,Bai, H.,McCracken, M.K.,Mason, R.D.,Leggat, D.,Slike, B.M.,Tran, U.,Jian, N.,Abbink, P.,Peterson, R.,Mendes, E.A.,Freitas de Oliveira Franca, R.,Calvet, G.A.,Bispo de Filippis, A.M.,McDermott, A.,Roederer, M.,Hernandez, M.,Albertus, A.,Davidson, E.,Doranz, B.J.,Rolland, M.,Robb, M.L.,Lynch, R.M.,Barouch, D.H.,Jarman, R.G.,Thomas, S.J.,Modjarrad, K.,Michael, N.L.,Krebs, S.J.,Joyce, M.G.; Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.; Cell Rep, 42:112942-112942, 2023; PubMed: 37561630; DOI: 10.1016/j.celrep.2023.112942

Experimental method

X-RAY DIFFRACTION (3.487 Å)