8E4Y

Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with 2-oxohexadecyl-CoA

8E4Y の概要

• エントリーDOI: 10.2210/pdb8e4y/pdb
• 関連するPDBエントリー: 8E50
• EMDBエントリー: 27898
• 分子名称: Glycerol-3-phosphate acyltransferase 1, mitochondrial, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2-oxohexadecyl)sulfanyl]ethyl}amino)propyl]amino}butyl dihydrogen diphosphate (non-preferred name), (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (3 entities in total)
• 機能のキーワード: acyltransferase, lpa, monotopic, mitochondrial, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 88335.89

構造登録者

Johnson, Z.L.,Wasilko, D.J.,Ammirati, M.,Chang, J.S.,Han, S.,Wu, H. (登録日: 2022-08-19, 公開日: 2022-12-21, 最終更新日: 2023-02-01)

• 主引用文献: Johnson, Z.L.,Ammirati, M.,Wasilko, D.J.,Chang, J.S.,Noell, S.,Foley, T.L.,Yoon, H.,Smith, K.,Asano, S.,Hales, K.,Wan, M.,Yang, Q.,Piotrowski, M.A.,Farley, K.A.,Gilbert, T.,Aschenbrenner, L.M.,Fennell, K.F.,Dutra, J.K.,Xu, M.,Guo, C.,Varghese, A.E.,Bellenger, J.,Quinn, A.,Am Ende, C.W.,West, G.M.,Griffor, M.C.,Bennett, D.,Calabrese, M.,Steppan, C.M.,Han, S.,Wu, H.; Structural basis of the acyl-transfer mechanism of human GPAT1.; Nat.Struct.Mol.Biol., 30:22-30, 2023; PubMed: 36522428; DOI: 10.1038/s41594-022-00884-7

実験手法

ELECTRON MICROSCOPY (3.4 Å)