8E4X
Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site
Summary for 8E4X
Entry DOI | 10.2210/pdb8e4x/pdb |
Related | 8e0f |
Descriptor | Double-stranded RNA-specific editase 1, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*(4DU)*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3), ... (6 entities in total) |
Functional Keywords | protein-rna complex, rna editing, rna binding protein, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 129981.67 |
Authors | Fisher, A.J.,Mendoza, H.G. (deposition date: 2022-08-19, release date: 2022-10-26, Last modification date: 2023-10-18) |
Primary citation | Doherty, E.E.,Karki, A.,Wilcox, X.E.,Mendoza, H.G.,Manjunath, A.,Matos, V.J.,Fisher, A.J.,Beal, P.A. ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site. Nucleic Acids Res., 50:10857-10868, 2022 Cited by PubMed: 36243986DOI: 10.1093/nar/gkac897 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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