8E4X

Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Double-stranded RNA-specific editase 1	polymer	488	53989.7	2	UniProt (P78563) Pfam (PF00035) Pfam (PF02137) In PDB	Homo sapiens (human)	RNA-editing deaminase 1,RNA-editing enzyme 1,dsRNA adenosine deaminase
2	C	RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3)	polymer	32	10355.2	1		Homo sapiens
3	D	RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*(4DU)*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3)	polymer	32	10196.2	1		Homo sapiens
4	A, B	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	2	Chemie (IHP)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	38	Chemie (HOH)

Sequence modifications

A, B: 215 - 701 (UniProt: P78563)

PDB	External Database	Details
Gly 214	-	expression tag
Gln 488	Glu 516	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	128530.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1450.9
All*	Total formula weight	129981.7

*Water molecules are not included.