8DT4

X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime MMB4 (POX-hAChE-MMB4)

Summary for 8DT4

Entry DOI	10.2210/pdb8dt4/pdb
Related	8DT2
Descriptor	Acetylcholinesterase, DIETHYL PHOSPHONATE, 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, ... (5 entities in total)
Functional Keywords	acetylcholine hydrolysis, oxime reactivator, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	121921.27
Authors	Kovalevsky, A.Y.,Gerlits, O.,Radic, Z. (deposition date: 2022-07-25, release date: 2022-11-02, Last modification date: 2023-10-18)
Primary citation	Gerlits, O.,Fajer, M.,Cheng, X.,Blumenthal, D.K.,Radic, Z.,Kovalevsky, A. Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure, 30:1538-1549.e3, 2022 Cited by PubMed: 36265484 DOI: 10.1016/j.str.2022.09.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation