8DND
Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)
Summary for 8DND
Entry DOI | 10.2210/pdb8dnd/pdb |
Related | 2Q2J 6PWH 7LYE |
Descriptor | Basic phospholipase A2 homolog piratoxin-1, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | prtx-i, varespladib, bothrops pirajai, pla2-like toxin, toxin, toxin-antitoxin complex, toxin/antitoxin |
Biological source | Bothrops pirajai |
Total number of polymer chains | 2 |
Total formula weight | 29033.64 |
Authors | Salvador, G.H.M.,Fontes, M.R.M. (deposition date: 2022-07-11, release date: 2023-08-02, Last modification date: 2023-08-09) |
Primary citation | Salvador, G.H.M.,Pinto, E.K.R.,Ortolani, P.L.,Fortes-Dias, C.L.,Cavalcante, W.L.G.,Soares, A.M.,Lomonte, B.,Lewin, M.R.,Fontes, M.R.M. Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib. Biochimie, 207:1-10, 2023 Cited by PubMed: 36403756DOI: 10.1016/j.biochi.2022.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.018 Å) |
Structure validation
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