8DJ3
Caspase-7 bound to novel allosteric inhibitor
Summary for 8DJ3
Entry DOI | 10.2210/pdb8dj3/pdb |
Descriptor | Caspase-7, 2-[(2-{[(3s,5s,7s)-adamantan-1-yl]sulfamoyl}phenyl)sulfanyl]benzoic acid (3 entities in total) |
Functional Keywords | allostery, inhibitor, ternary, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69575.77 |
Authors | Propp, J.,Kalenkiewicz, A.,Kathryn, F.H.,Spies, M.A. (deposition date: 2022-06-29, release date: 2023-07-05, Last modification date: 2023-10-25) |
Primary citation | Hobbs, K.F.,Propp, J.,Vance, N.R.,Kalenkiewicz, A.,Witkin, K.R.,Ashley Spies, M. Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power. Chemistry, 29:e202300872-e202300872, 2023 Cited by PubMed: 37005499DOI: 10.1002/chem.202300872 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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