8DJ3
Caspase-7 bound to novel allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Caspase-7 | polymer | 305 | 34566.1 | 2 | UniProt (P55210) Pfam (PF00656) | Homo sapiens (human) | CASP-7,Apoptotic protease Mch-3,CMH-1,ICE-like apoptotic protease 3,ICE-LAP3 |
| 2 | C (A) | 2-[(2-{[(3s,5s,7s)-adamantan-1-yl]sulfamoyl}phenyl)sulfanyl]benzoic acid | non-polymer | 443.6 | 1 | Chemie (SE1) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 303 (UniProt: P55210)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Leu 0 | - | expression tag |
| Glu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69132.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 443.6 | |
| All* | Total formula weight | 69575.8 |
