8DGZ

Caspase-7 bound to substrate mimic and allosteric inhibitor

Summary for 8DGZ

• Entry DOI: 10.2210/pdb8dgz/pdb
• Related PRD ID: PRD_000422
• Descriptor: Caspase-7, Ac-Asp-Glu-Val-Asp-Aldehyde, 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid (3 entities in total)
• Functional Keywords: allostery, inhibitor, ternary, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 70415.94

Authors

Propp, J.,Kalenkiewicz, A.,Kathryn, F.H.,Spies, M.A. (deposition date: 2022-06-24, release date: 2023-07-05, Last modification date: 2023-11-22)

• Primary citation: Hobbs, K.F.,Propp, J.,Vance, N.R.,Kalenkiewicz, A.,Witkin, K.R.,Ashley Spies, M.; Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.; Chemistry, 29:e202300872-e202300872, 2023; PubMed: 37005499; DOI: 10.1002/chem.202300872

Experimental method

X-RAY DIFFRACTION (2.8 Å)