8DGZ
Caspase-7 bound to substrate mimic and allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Caspase-7 | polymer | 305 | 34566.1 | 2 | UniProt (P55210) Pfam (PF00656) | Homo sapiens (Human) | CASP-7,Apoptotic protease Mch-3,CMH-1,ICE-like apoptotic protease 3,ICE-LAP3 |
| 2 | C, D (C, D) | Ac-Asp-Glu-Val-Asp-Aldehyde | polymer | 5 | 488.5 | 2 | BIRD (PRD_000422) | synthetic construct | |
| 3 | E (B) | 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid | non-polymer | 306.8 | 1 | Chemie (8YJ) |
Sequence modifications
A, B: 2 - 303 (UniProt: P55210)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Leu 0 | - | expression tag |
| Glu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70109.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 306.8 | |
| All* | Total formula weight | 70415.9 |
