8DFQ

Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers

Summary for 8DFQ

Entry DOI	10.2210/pdb8dfq/pdb
EMDB information	27411
Descriptor	Isoform 2 of Mast/stem cell growth factor receptor Kit, Soluble KIT ligand, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	receptor tyrosine kinase, cell signaling, cancer, cryo-em, kit, stem cell factor, oncogenic mutant, extracellular domain, asymmetric interface, structural plasticity, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	254290.63
Authors	Krimmer, S.G.,Bertoletti, N.,Mi, W.,Schlessinger, J. (deposition date: 2022-06-22, release date: 2023-03-29, Last modification date: 2023-04-05)
Primary citation	Krimmer, S.G.,Bertoletti, N.,Suzuki, Y.,Katic, L.,Mohanty, J.,Shu, S.,Lee, S.,Lax, I.,Mi, W.,Schlessinger, J. Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120:e2300054120-e2300054120, 2023 Cited by PubMed: 36943885 DOI: 10.1073/pnas.2300054120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.96 Å)

Structure validation