8DCH

Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x with GRL-0519 (tris-tetrahydrofuran as P2 ligand)

8DCH の概要

• エントリーDOI: 10.2210/pdb8dch/pdb
• 関連するPDBエントリー: 3PWM 3PWR 6DIL 6DJ2 6DJ5 8DCI
• 分子名称: Protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv/aids, hiv protease, drug resistant clinical mutant, evolution of drug resistance, distal mutations, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22336.83

構造登録者

Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (登録日: 2022-06-16, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Wong-Sam, A.,Wang, Y.F.,Kneller, D.W.,Kovalevsky, A.Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.; J.Mol.Graph.Model., 117:108315-108315, 2022; PubMed: 36108568; DOI: 10.1016/j.jmgm.2022.108315

実験手法

X-RAY DIFFRACTION (1.25 Å)