8DC8

Crystal structure of p53 Y220C covalently bound to azaindole KG13

Summary for 8DC8

• Entry DOI: 10.2210/pdb8dc8/pdb
• Descriptor: Cellular tumor antigen p53, 2-methyl-1-[(4P)-3-methyl-4-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl]prop-2-en-1-one, bound form, SULFATE ION, ... (6 entities in total)
• Functional Keywords: tp53, tumor suppressor, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 25383.16

Authors

Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-06-15, release date: 2022-10-12, Last modification date: 2023-10-25)

• Primary citation: Guiley, K.Z.,Shokat, K.M.; A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.; Cancer Discov, 13:56-69, 2023; PubMed: 36197521; DOI: 10.1158/2159-8290.CD-22-0381

Experimental method

X-RAY DIFFRACTION (1.72009735908 Å)