8DC6

Crystal structure of p53 Y220C covalently bound to indole KG6

Summary for 8DC6

Entry DOI	10.2210/pdb8dc6/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	p53, tp53, tumor suppressor, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	101924.12
Authors	Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-06-15, release date: 2022-10-12, Last modification date: 2023-10-25)
Primary citation	Guiley, K.Z.,Shokat, K.M. A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. Cancer Discov, 13:56-69, 2023 Cited by PubMed: 36197521 DOI: 10.1158/2159-8290.CD-22-0381 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.60000908706 Å)

Structure validation