8DC4

Crystal structure of p53 Y220C covalently bound to carbazole KG3

Summary for 8DC4

Entry DOI	10.2210/pdb8dc4/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, 9-propanoyl-9H-carbazole-3-carbaldehyde, bound form, ... (4 entities in total)
Functional Keywords	tp53, tumor suppressor, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	100770.82
Authors	Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-06-15, release date: 2022-10-12, Last modification date: 2023-10-25)
Primary citation	Guiley, K.Z.,Shokat, K.M. A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. Cancer Discov, 13:56-69, 2023 Cited by PubMed: 36197521 DOI: 10.1158/2159-8290.CD-22-0381 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation