8DC4
Crystal structure of p53 Y220C covalently bound to carbazole KG3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, A, C, D) | Cellular tumor antigen p53 | polymer | 223 | 24876.0 | 4 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | E, G, I, K (B, A, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, H, J, L (B, A, C, D) | 9-propanoyl-9H-carbazole-3-carbaldehyde, bound form | non-polymer | 251.3 | 4 | Chemie (R3R) | |||
| 4 | M, N, O, P (B, A, C, D) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
B, A, C, D: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Gly 90 | - | expression tag |
| Ala 91 | - | expression tag |
| His 92 | - | expression tag |
| Met 93 | - | expression tag |
| Ser 124 | Cys 124 | conflict |
| Leu 133 | Met 133 | conflict |
| Ser 182 | Cys 182 | conflict |
| Cys 220 | Tyr 220 | engineered mutation |
| Ser 229 | Cys 229 | conflict |
| Tyr 239 | Asn 239 | conflict |
| Asp 268 | Asn 268 | conflict |
| Ser 275 | Cys 275 | conflict |
| Ser 277 | Cys 277 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99504.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1266.8 | |
| All* | Total formula weight | 100770.8 |
