8DAF

Human SF-1 LBD bound to synthetic agonist 6N-10CA and bacterial phospholipid

8DAF の概要

• エントリーDOI: 10.2210/pdb8daf/pdb
• 分子名称: Steroidogenic factor 1, Nuclear receptor coactivator 2, 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), ... (5 entities in total)
• 機能のキーワード: sf-1, nuclear receptor, ligand, synthetic agonist, nuclear protein, steroidogenic factor-1, nr5a1
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62140.51

構造登録者

D'Agostino, E.H.,Cato, M.L.,Ortlund, E.A. (登録日: 2022-06-13, 公開日: 2023-06-28, 最終更新日: 2023-10-25)

• 主引用文献: Cato, M.L.,D'Agostino, E.H.,Spurlin, R.M.,Flynn, A.R.,Cornelison, J.L.,Johnson, A.M.,Fujita, R.A.,Abraham, S.M.,Jui, N.T.,Ortlund, E.A.; Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators.; J.Biol.Chem., 299:104921-104921, 2023; PubMed: 37328104; DOI: 10.1016/j.jbc.2023.104921

実験手法

X-RAY DIFFRACTION (2.59 Å)