8D59

Crystal structure of human METTL1 in complex with SAM

Summary for 8D59

• Entry DOI: 10.2210/pdb8d59/pdb
• Descriptor: tRNA (guanine-N(7)-)-methyltransferase, S-ADENOSYLMETHIONINE, GLYCEROL, ... (7 entities in total)
• Functional Keywords: cancer protein, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 31267.81

Authors

Raj, R.,Babu, K.,Nam, Y. (deposition date: 2022-06-04, release date: 2023-01-11, Last modification date: 2023-10-25)

• Primary citation: Ruiz-Arroyo, V.M.,Raj, R.,Babu, K.,Onolbaatar, O.,Roberts, P.H.,Nam, Y.; Structures and mechanisms of tRNA methylation by METTL1-WDR4.; Nature, 613:383-390, 2023; PubMed: 36599982; DOI: 10.1038/s41586-022-05565-5

Experimental method

X-RAY DIFFRACTION (2.26 Å)