8D59
Crystal structure of human METTL1 in complex with SAM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | tRNA (guanine-N(7)-)-methyltransferase | polymer | 262 | 30412.7 | 1 | UniProt (Q9UBP6) Pfam (PF02390) | Homo sapiens (human) | Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase |
| 2 | B (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, G (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | E (A) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 6 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | H (A) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 20 - 265 (UniProt: Q9UBP6)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | - | initiating methionine |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| Glu 11 | - | expression tag |
| Asn 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Phe 15 | - | expression tag |
| Gln 16 | - | expression tag |
| Gly 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gly 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30412.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 855.1 | |
| All* | Total formula weight | 31267.8 |
