8D59

Crystal structure of human METTL1 in complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006400	biological_process	tRNA modification
A	0008176	molecular_function	tRNA (guanine(46)-N7)-methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Alpha6 helix","evidences":[{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"36599982","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36599982","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human methyltransferase-like protein 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3CKK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D9L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36599985","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human methyltransferase-like protein 1.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3CKK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---