8D35
Crystal structure of SARS-CoV-2 main protease (Mpro) C145A mutant in complex with peptide from human tRNA methyltransferase TRMT1
Summary for 8D35
Entry DOI | 10.2210/pdb8d35/pdb |
Descriptor | 3C-like proteinase nsp5, tRNA (guanine(26)-N(2))-dimethyltransferase, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | protease, host-virus protein interaction, rna modifying enzyme, viral protein, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 3 |
Total formula weight | 69579.47 |
Authors | D'Oliviera, A.,Mugridge, J.S. (deposition date: 2022-05-31, release date: 2023-03-01, Last modification date: 2023-11-22) |
Primary citation | D'Oliviera, A.,Dai, X.,Mottaghinia, S.,Geissler, E.P.,Etienne, L.,Zhang, Y.,Mugridge, J.S. Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease. Elife, 2023 Cited by DOI: 10.7554/eLife.91168.1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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