9DW6
Crystal structure of SARS-CoV-2 main protease (Mpro) C145A mutant in complex with peptide from human tRNA methyltransferase TRMT1
Replaces: 8D35Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C-like proteinase nsp5 | polymer | 308 | 33937.6 | 2 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | C (C) | tRNA (guanine(26)-N(2))-dimethyltransferase | polymer | 11 | 1346.5 | 1 | UniProt (Q9NXH9) | Homo sapiens | tRNA 2,2-dimethylguanosine-26 methyltransferase,tRNA(guanine-26,N(2)-N(2)) methyltransferase,tRNA(m(2,2)G26)dimethyltransferase |
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E, G (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | I, J, K (A, B, C) | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 145 | Cys 3408 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69221.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 265.6 | |
| All* | Total formula weight | 69487.4 |
