8D0S

Human FUT9 bound to GDP and LNnT

Summary for 8D0S

Entry DOI	10.2210/pdb8d0s/pdb
Related	8D0O 8D0P 8D0Q 8D0R
Descriptor	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... (7 entities in total)
Functional Keywords	glycosyltransferase, alpha-(1, 3)-fucosyltransferase, gt 10, gt-b fold, inverting mechanism, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40160.46
Authors	Kadirvelraj, R.,Wood, Z.A. (deposition date: 2022-05-26, release date: 2023-05-24, Last modification date: 2023-10-25)
Primary citation	Kadirvelraj, R.,Boruah, B.M.,Wang, S.,Chapla, D.,Huang, C.,Ramiah, A.,Hudson, K.L.,Prudden, A.R.,Boons, G.J.,Withers, S.G.,Wood, Z.A.,Moremen, K.W. Structural basis for Lewis antigen synthesis by the alpha 1,3-fucosyltransferase FUT9. Nat.Chem.Biol., 19:1022-1030, 2023 Cited by PubMed: 37202521 DOI: 10.1038/s41589-023-01345-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.37 Å)

Structure validation