8D0M

Human CD38 ectodomain bound to a 78c-ADPR adduct

Summary for 8D0M

Entry DOI	10.2210/pdb8d0m/pdb
Related	8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0J
Descriptor	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[5-[4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-2-oxidanylidene-quinolin-6-yl]-1,3-thiazol-3-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
Functional Keywords	nad, hydrolase, axon degeneration, neuroscience, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31628.53
Authors	Bratkowski, M.A.,Gu, W. (deposition date: 2022-05-26, release date: 2022-09-21, Last modification date: 2023-10-25)
Primary citation	Bratkowski, M.,Burdett, T.C.,Danao, J.,Wang, X.,Mathur, P.,Gu, W.,Beckstead, J.A.,Talreja, S.,Yang, Y.S.,Danko, G.,Park, J.H.,Walton, M.,Brown, S.P.,Tegley, C.M.,Joseph, P.R.B.,Reynolds, C.H.,Sambashivan, S. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron, 110:3711-, 2022 Cited by PubMed: 36087583 DOI: 10.1016/j.neuron.2022.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation