8D0M
Human CD38 ectodomain bound to a 78c-ADPR adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | polymer | 265 | 30672.7 | 1 | UniProt (P28907) Pfam (PF02267) | Homo sapiens (human) | 2'-phospho-ADP-ribosyl cyclase,2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase,2'-phospho-cyclic-ADP-ribose transferase,ADP-ribosyl cyclase 1,ADPRC 1,Cyclic ADP-ribose hydrolase 1,cADPr hydrolase 1,T10 |
| 2 | B (A) | [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[5-[4-[[4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-2-oxidanylidene-quinolin-6-yl]-1,3-thiazol-3-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | non-polymer | 955.8 | 1 | Chemie (Q2C) | |||
| 3 | C (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Asp 100 | Asn 100 | engineered mutation |
| Ala 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
| Gly 301 | - | expression tag |
| Gly 302 | - | expression tag |
| Ser 303 | - | expression tag |
| Glu 304 | - | expression tag |
| Asn 305 | - | expression tag |
| Leu 306 | - | expression tag |
| Tyr 307 | - | expression tag |
| Phe 308 | - | expression tag |
| Gln 309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30672.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 955.8 | |
| All* | Total formula weight | 31628.5 |
