8D0J

Apo Human SARM1 TIR domain

Summary for 8D0J

• Entry DOI: 10.2210/pdb8d0j/pdb
• Related: 8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0M
• Descriptor: NAD(+) hydrolase SARM1 (2 entities in total)
• Functional Keywords: nad, hydrolase, axon degeneration, neuroscience
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 32411.15

Authors

Bratkowski, M.A.,Mathur, P. (deposition date: 2022-05-26, release date: 2022-09-21, Last modification date: 2024-04-03)

• Primary citation: Bratkowski, M.,Burdett, T.C.,Danao, J.,Wang, X.,Mathur, P.,Gu, W.,Beckstead, J.A.,Talreja, S.,Yang, Y.S.,Danko, G.,Park, J.H.,Walton, M.,Brown, S.P.,Tegley, C.M.,Joseph, P.R.B.,Reynolds, C.H.,Sambashivan, S.; Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.; Neuron, 110:3711-, 2022; PubMed: 36087583; DOI: 10.1016/j.neuron.2022.08.017

Experimental method

X-RAY DIFFRACTION (1.94 Å)