8D0E

Human SARM1 TIR domain bound to NB-7

Summary for 8D0E

Entry DOI	10.2210/pdb8d0e/pdb
Related	8D0C 8D0D 8D0F 8D0G 8D0H 8D0I 8D0J 8D0M
Descriptor	NAD(+) hydrolase SARM1, 3-(4-chlorophenyl)-N-[4-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl]propanamide (3 entities in total)
Functional Keywords	nad, hydrolase, axon degeneration, neuroscience, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	33092.76
Authors	Bratkowski, M.A.,Mathur, P. (deposition date: 2022-05-26, release date: 2022-09-21, Last modification date: 2023-10-25)
Primary citation	Bratkowski, M.,Burdett, T.C.,Danao, J.,Wang, X.,Mathur, P.,Gu, W.,Beckstead, J.A.,Talreja, S.,Yang, Y.S.,Danko, G.,Park, J.H.,Walton, M.,Brown, S.P.,Tegley, C.M.,Joseph, P.R.B.,Reynolds, C.H.,Sambashivan, S. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron, 110:3711-, 2022 Cited by PubMed: 36087583 DOI: 10.1016/j.neuron.2022.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation