8CZA

Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-IV-075

8CZA の概要

• エントリーDOI: 10.2210/pdb8cza/pdb
• 分子名称: Bromodomain testis-specific protein, 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: brdt, brd, bet, gene regulation, contraceptive, cancer
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 84087.20

構造登録者

Chan, A.,Schonbrunn, E. (登録日: 2022-05-24, 公開日: 2022-08-03, 最終更新日: 2023-10-18)

• 主引用文献: Guan, X.,Cheryala, N.,Karim, R.M.,Chan, A.,Berndt, N.,Qi, J.,Georg, G.I.,Schonbrunn, E.; Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.; J.Med.Chem., 65:10441-10458, 2022; PubMed: 35867655; DOI: 10.1021/acs.jmedchem.2c00453

実験手法

X-RAY DIFFRACTION (2.96 Å)