8CYI

Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5

8CYI の概要

• エントリーDOI: 10.2210/pdb8cyi/pdb
• EMDBエントリー: 27078
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: prmt5, protein arginine methyl transferase, mta-inhibitor synergy, cryo-em structure-based drug design, computational analysis, catalytic mechanism, drug discovery, docking analysis, oncoprotein, oncoprotein-transferase complex, oncoprotein/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 106704.71

構造登録者

Yadav, G.P.,Wei, Z.,Xiaozhi, Y.,Chenglong, L.,Jiang, Q. (登録日: 2022-05-23, 公開日: 2023-04-12, 最終更新日: 2024-06-12)

• 主引用文献: Zhou, W.,Yadav, G.P.,Yang, X.,Qin, F.,Li, C.,Jiang, Q.X.; Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency.; Commun Biol, 5:1054-1054, 2022; PubMed: 36192627; DOI: 10.1038/s42003-022-03991-9

実験手法

ELECTRON MICROSCOPY (3.14 Å)