8CYH

Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics

8CYH の概要

• エントリーDOI: 10.2210/pdb8cyh/pdb
• 分子名称: A12 antibody light chain, A12 antibody heavy chain, Mesothelin, cleaved form, ... (4 entities in total)
• 機能のキーワード: antibody, complex, tumor associated antigen, antitumor protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 84039.52

構造登録者

Bandaranayake, A.D.,Rupert, P.B.,Lin, I.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Carter, J.,Meshinchi, S.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E. (登録日: 2022-05-23, 公開日: 2023-06-07, 最終更新日: 2023-12-20)

• 主引用文献: Lin, I.,Rupert, P.B.,Pilat, K.,Ruff, R.O.,Friend, D.J.,Chan, M.K.,Clarke, M.,Hoffstrom, B.G.,Carter, J.,Meshinchi, S.,Bandaranayake, A.D.,Mehlin, C.,Olson, J.M.,Strong, R.K.,Correnti, C.E.; Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics; Front. Drug Discov., 3:-, 2023; DOI: 10.3389/fddsv.2023.1216516

実験手法

X-RAY DIFFRACTION (3.38 Å)