8CVM
Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map
Summary for 8CVM
Entry DOI | 10.2210/pdb8cvm/pdb |
Related | 8CRX |
EMDB information | 27009 |
Descriptor | 50S ribosomal protein L2, 50S ribosomal protein L17, 50S ribosomal protein L18, ... (36 entities in total) |
Functional Keywords | ribosome, sarecycline, acne, antibiotic |
Biological source | Cutibacterium acnes More |
Total number of polymer chains | 32 |
Total formula weight | 1474840.64 |
Authors | Lomakin, I.B.,Devarkar, S.C.,Bunick, C.G. (deposition date: 2022-05-18, release date: 2023-03-15, Last modification date: 2023-04-19) |
Primary citation | Lomakin, I.B.,Devarkar, S.C.,Patel, S.,Grada, A.,Bunick, C.G. Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res., 51:2915-2930, 2023 Cited by PubMed: 36864821DOI: 10.1093/nar/gkad103 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.66 Å) |
Structure validation
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