Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8CVM

Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0003735	molecular_function	structural constituent of ribosome
0	0005737	cellular_component	cytoplasm
0	0005840	cellular_component	ribosome
0	0006412	biological_process	translation
0	1990904	cellular_component	ribonucleoprotein complex
1	0003735	molecular_function	structural constituent of ribosome
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
1	1990904	cellular_component	ribonucleoprotein complex
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	0015934	cellular_component	large ribosomal subunit
2	0022625	cellular_component	cytosolic large ribosomal subunit
2	1990904	cellular_component	ribonucleoprotein complex
3	0003735	molecular_function	structural constituent of ribosome
3	0005737	cellular_component	cytoplasm
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
3	1990904	cellular_component	ribonucleoprotein complex
4	0003723	molecular_function	RNA binding
4	0003735	molecular_function	structural constituent of ribosome
4	0005840	cellular_component	ribosome
4	0006412	biological_process	translation
4	0019843	molecular_function	rRNA binding
4	0046872	molecular_function	metal ion binding
4	1990904	cellular_component	ribonucleoprotein complex
c	0002181	biological_process	cytoplasmic translation
c	0003723	molecular_function	RNA binding
c	0003735	molecular_function	structural constituent of ribosome
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
c	0015934	cellular_component	large ribosomal subunit
c	0016740	molecular_function	transferase activity
c	0019843	molecular_function	rRNA binding
c	1990904	cellular_component	ribonucleoprotein complex
d	0003723	molecular_function	RNA binding
d	0003735	molecular_function	structural constituent of ribosome
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
d	0019843	molecular_function	rRNA binding
d	0022625	cellular_component	cytosolic large ribosomal subunit
d	1990904	cellular_component	ribonucleoprotein complex
e	0003723	molecular_function	RNA binding
e	0003735	molecular_function	structural constituent of ribosome
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	0019843	molecular_function	rRNA binding
e	1990904	cellular_component	ribonucleoprotein complex
f	0000049	molecular_function	tRNA binding
f	0003723	molecular_function	RNA binding
f	0003735	molecular_function	structural constituent of ribosome
f	0005840	cellular_component	ribosome
f	0006412	biological_process	translation
f	0019843	molecular_function	rRNA binding
f	1990904	cellular_component	ribonucleoprotein complex
g	0002181	biological_process	cytoplasmic translation
g	0003723	molecular_function	RNA binding
g	0003735	molecular_function	structural constituent of ribosome
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
g	0019843	molecular_function	rRNA binding
g	0022625	cellular_component	cytosolic large ribosomal subunit
g	1990904	cellular_component	ribonucleoprotein complex
i	0003729	molecular_function	mRNA binding
i	0003735	molecular_function	structural constituent of ribosome
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	0017148	biological_process	negative regulation of translation
i	0022625	cellular_component	cytosolic large ribosomal subunit
i	1990904	cellular_component	ribonucleoprotein complex
j	0003723	molecular_function	RNA binding
j	0003735	molecular_function	structural constituent of ribosome
j	0005840	cellular_component	ribosome
j	0006412	biological_process	translation
j	0015934	cellular_component	large ribosomal subunit
j	0019843	molecular_function	rRNA binding
j	0022625	cellular_component	cytosolic large ribosomal subunit
j	0070180	molecular_function	large ribosomal subunit rRNA binding
j	1990904	cellular_component	ribonucleoprotein complex
k	0003723	molecular_function	RNA binding
k	0003735	molecular_function	structural constituent of ribosome
k	0005840	cellular_component	ribosome
k	0006412	biological_process	translation
k	0015934	cellular_component	large ribosomal subunit
k	0019843	molecular_function	rRNA binding
k	0022625	cellular_component	cytosolic large ribosomal subunit
k	1990904	cellular_component	ribonucleoprotein complex
l	0000049	molecular_function	tRNA binding
l	0003723	molecular_function	RNA binding
l	0003735	molecular_function	structural constituent of ribosome
l	0005840	cellular_component	ribosome
l	0006412	biological_process	translation
l	0019843	molecular_function	rRNA binding
l	0022625	cellular_component	cytosolic large ribosomal subunit
l	1990904	cellular_component	ribonucleoprotein complex
m	0003735	molecular_function	structural constituent of ribosome
m	0005840	cellular_component	ribosome
m	0006412	biological_process	translation
n	0003723	molecular_function	RNA binding
n	0003735	molecular_function	structural constituent of ribosome
n	0005737	cellular_component	cytoplasm
n	0005840	cellular_component	ribosome
n	0006412	biological_process	translation
n	0008097	molecular_function	5S rRNA binding
n	0019843	molecular_function	rRNA binding
n	0022625	cellular_component	cytosolic large ribosomal subunit
n	1990904	cellular_component	ribonucleoprotein complex
o	0003735	molecular_function	structural constituent of ribosome
o	0005840	cellular_component	ribosome
o	0006412	biological_process	translation
o	0022625	cellular_component	cytosolic large ribosomal subunit
o	1990904	cellular_component	ribonucleoprotein complex
p	0000027	biological_process	ribosomal large subunit assembly
p	0003723	molecular_function	RNA binding
p	0003735	molecular_function	structural constituent of ribosome
p	0005840	cellular_component	ribosome
p	0006412	biological_process	translation
p	0019843	molecular_function	rRNA binding
p	1990904	cellular_component	ribonucleoprotein complex
q	0003723	molecular_function	RNA binding
q	0003735	molecular_function	structural constituent of ribosome
q	0005737	cellular_component	cytoplasm
q	0005840	cellular_component	ribosome
q	0006412	biological_process	translation
q	0019843	molecular_function	rRNA binding
q	1990904	cellular_component	ribonucleoprotein complex
r	0003723	molecular_function	RNA binding
r	0003735	molecular_function	structural constituent of ribosome
r	0005840	cellular_component	ribosome
r	0006412	biological_process	translation
r	0015934	cellular_component	large ribosomal subunit
r	0019843	molecular_function	rRNA binding
r	0022625	cellular_component	cytosolic large ribosomal subunit
r	1990904	cellular_component	ribonucleoprotein complex
s	0003723	molecular_function	RNA binding
s	0003735	molecular_function	structural constituent of ribosome
s	0005840	cellular_component	ribosome
s	0006412	biological_process	translation
s	0019843	molecular_function	rRNA binding
s	1990904	cellular_component	ribonucleoprotein complex
t	0003723	molecular_function	RNA binding
t	0003735	molecular_function	structural constituent of ribosome
t	0005840	cellular_component	ribosome
t	0006412	biological_process	translation
t	0019843	molecular_function	rRNA binding
t	1990904	cellular_component	ribonucleoprotein complex
u	0003723	molecular_function	RNA binding
u	0003735	molecular_function	structural constituent of ribosome
u	0005840	cellular_component	ribosome
u	0006412	biological_process	translation
u	0008097	molecular_function	5S rRNA binding
u	0019843	molecular_function	rRNA binding
u	0022625	cellular_component	cytosolic large ribosomal subunit
u	1990904	cellular_component	ribonucleoprotein complex
v	0003735	molecular_function	structural constituent of ribosome
v	0005840	cellular_component	ribosome
v	0006412	biological_process	translation
v	0022625	cellular_component	cytosolic large ribosomal subunit
v	1990904	cellular_component	ribonucleoprotein complex
w	0003735	molecular_function	structural constituent of ribosome
w	0005840	cellular_component	ribosome
w	0006412	biological_process	translation
w	1990904	cellular_component	ribonucleoprotein complex
x	0003735	molecular_function	structural constituent of ribosome
x	0005840	cellular_component	ribosome
x	0006412	biological_process	translation
x	0022625	cellular_component	cytosolic large ribosomal subunit
x	1990904	cellular_component	ribonucleoprotein complex
y	0003735	molecular_function	structural constituent of ribosome
y	0005840	cellular_component	ribosome
y	0006412	biological_process	translation
y	0015934	cellular_component	large ribosomal subunit
y	0022625	cellular_component	cytosolic large ribosomal subunit
y	1990904	cellular_component	ribonucleoprotein complex
z	0003735	molecular_function	structural constituent of ribosome
z	0005840	cellular_component	ribosome
z	0006412	biological_process	translation
z	0015934	cellular_component	large ribosomal subunit
z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RriRpRAkGSasrilkrsAHITVvV

Chain	Residue	Details
r	ARG100-VAL124

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsnrrRarnh.GFrsR

Chain	Residue	Details
1	LYS2-ARG21

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GeIIvRQRGthfhpG

Chain	Residue	Details
v	GLY34-GLY48

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FsesdfvDvtGtSkGKGtaGvmkR

Chain	Residue	Details
d	PHE107-ARG130

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CdkCkvIrRhgrVmViCdnp.RHkQrQ

Chain	Residue	Details
3	CYS11-GLN36

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRgGKVWINVYP

Chain	Residue	Details
l	LYS59-PRO70

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGsGKGtpewW

Chain	Residue	Details
l	ARG82-TRP93

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. NTARLReVRKDIARV

Chain	Residue	Details
x	ASN42-VAL56

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YiTkKNrrnnPdrMEmaKFC

Chain	Residue	Details
0	TYR24-CYS43

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDrVkVIaGndKGai.GeV

Chain	Residue	Details
t	GLY9-VAL26

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGVVmNPiD

Chain	Residue	Details
c	PRO219-ASP230

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VdRhGAVR.RAKLYYLR

Chain	Residue	Details
o	VAL86-ARG101

site_id	PS01169
Number of Residues	23
Details	RIBOSOMAL_L21 Ribosomal protein L21 signature. IrilKyknKTgykkrqGHRQkyT

Chain	Residue	Details
q	ILE71-THR93

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtvkshrrp.DGsyikFdeNaaVL

Chain	Residue	Details
j	ALA60-LEU86

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KgdfRsLWIQRINaasR

Chain	Residue	Details
p	LYS54-ARG70

site_id	PS01143
Number of Residues	22
Details	RIBOSOMAL_L31 Ribosomal protein L31 signature. DVcskcHPFYTgkqkildag....GR

Chain	Residue	Details
4	ASP36-ARG57

site_id	PS00525
Number of Residues	9
Details	RIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGV

Chain	Residue	Details
g	PRO156-VAL164

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	142
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	71
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00501","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)