8CVM

Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map

Summary for 8CVM

Entry DOI	10.2210/pdb8cvm/pdb
Related	8CRX
EMDB information	27009
Descriptor	50S ribosomal protein L2, 50S ribosomal protein L17, 50S ribosomal protein L18, ... (36 entities in total)
Functional Keywords	ribosome, sarecycline, acne, antibiotic
Biological source	Cutibacterium acnes More
Total number of polymer chains	32
Total formula weight	1474840.64
Authors	Lomakin, I.B.,Devarkar, S.C.,Bunick, C.G. (deposition date: 2022-05-18, release date: 2023-03-15, Last modification date: 2023-04-19)
Primary citation	Lomakin, I.B.,Devarkar, S.C.,Patel, S.,Grada, A.,Bunick, C.G. Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res., 51:2915-2930, 2023 Cited by PubMed: 36864821 DOI: 10.1093/nar/gkad103 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.66 Å)

Structure validation