8CT4

Cryo-EM structure of Mtb Lpd bound to inhibitor complex with 2-((2-cyano-N,5-dimethyl-1H-indole)-7-sulfonamido)-N-(4-(oxetan-3-yl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-7-yl)acetamide

Summary for 8CT4

• Entry DOI: 10.2210/pdb8ct4/pdb
• Related: 7kmy
• EMDB information: 26981
• Descriptor: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-(2-cyano-5-methyl-1H-indole-7-sulfonyl)-N~2~-methyl-N-[4-(oxetan-3-yl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl]glycinamide, ... (4 entities in total)
• Functional Keywords: flavoprotein, glycolysis, redox-active center, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 101436.27

Authors

Kochanczyk, T.,Arango, N.,Lima, C.D. (deposition date: 2022-05-13, release date: 2022-05-25, Last modification date: 2023-06-07)

• Primary citation: Kochanczyk, T.,Arango, N.,Michino, M.,Sun, S.,Ginn, J.,Bryk, R.,Nathan, C.,Lima, C.D.; Cryo-EM structure of Mtb Lpd bound to the inhibitor 2-((2-cyano-N,5-dimethyl-1H-indole)-7-sulfonamido)-N-(4-(oxetan-3-yl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-7-yl)acetamide at 2.17 Angstrom resolution; Not published,

Experimental method

ELECTRON MICROSCOPY (2.17 Å)