8CS4
[AGC/GTC] Self-Assembled 3D DNA Hexagonal Tensegrity Triangle
This is a non-PDB format compatible entry.
Summary for 8CS4
Entry DOI | 10.2210/pdb8cs4/pdb |
Related | 7R96 |
Descriptor | DNA (5'-D(*AP*GP*CP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*GP*GP*CP*TP*G)-3'), ... (4 entities in total) |
Functional Keywords | tensegrity triangle, synthetic construct, self-assembly, dna |
Biological source | synthetic construct More |
Total number of polymer chains | 4 |
Total formula weight | 12797.42 |
Authors | Lu, B.,Vecchioni, S.,Ohayon, Y.P.,Seeman, N.C.,Mao, C.,Sha, R. (deposition date: 2022-05-12, release date: 2023-01-11, Last modification date: 2023-10-25) |
Primary citation | Lu, B.,Woloszyn, K.,Ohayon, Y.P.,Yang, B.,Zhang, C.,Mao, C.,Seeman, N.C.,Vecchioni, S.,Sha, R. Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles. Angew.Chem.Int.Ed.Engl., 62:e202213451-e202213451, 2023 Cited by PubMed Abstract: Non-canonical interactions in DNA remain under-explored in DNA nanotechnology. Recently, many structures with non-canonical motifs have been discovered, notably a hexagonal arrangement of typically rhombohedral DNA tensegrity triangles that forms through non-canonical sticky end interactions. Here, we find a series of mechanisms to program a hexagonal arrangement using: the sticky end sequence; triangle edge torsional stress; and crystallization condition. We showcase cross-talking between Watson-Crick and non-canonical sticky ends in which the ratio between the two dictates segregation by crystal forms or combination into composite crystals. Finally, we develop a method for reconfiguring the long-range geometry of formed crystals from rhombohedral to hexagonal and vice versa. These data demonstrate fine control over non-canonical motifs and their topological self-assembly. This will vastly increase the programmability, functionality, and versatility of rationally designed DNA constructs. PubMed: 36520622DOI: 10.1002/anie.202213451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (6.03 Å) |
Structure validation
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