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8CS4

[AGC/GTC] Self-Assembled 3D DNA Hexagonal Tensegrity Triangle

This is a non-PDB format compatible entry.
Summary for 8CS4
Entry DOI10.2210/pdb8cs4/pdb
Related7R96
DescriptorDNA (5'-D(*AP*GP*CP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*GP*GP*CP*TP*G)-3'), ... (4 entities in total)
Functional Keywordstensegrity triangle, synthetic construct, self-assembly, dna
Biological sourcesynthetic construct
More
Total number of polymer chains4
Total formula weight12797.42
Authors
Lu, B.,Vecchioni, S.,Ohayon, Y.P.,Seeman, N.C.,Mao, C.,Sha, R. (deposition date: 2022-05-12, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citationLu, B.,Woloszyn, K.,Ohayon, Y.P.,Yang, B.,Zhang, C.,Mao, C.,Seeman, N.C.,Vecchioni, S.,Sha, R.
Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles.
Angew.Chem.Int.Ed.Engl., 62:e202213451-e202213451, 2023
Cited by
PubMed Abstract: Non-canonical interactions in DNA remain under-explored in DNA nanotechnology. Recently, many structures with non-canonical motifs have been discovered, notably a hexagonal arrangement of typically rhombohedral DNA tensegrity triangles that forms through non-canonical sticky end interactions. Here, we find a series of mechanisms to program a hexagonal arrangement using: the sticky end sequence; triangle edge torsional stress; and crystallization condition. We showcase cross-talking between Watson-Crick and non-canonical sticky ends in which the ratio between the two dictates segregation by crystal forms or combination into composite crystals. Finally, we develop a method for reconfiguring the long-range geometry of formed crystals from rhombohedral to hexagonal and vice versa. These data demonstrate fine control over non-canonical motifs and their topological self-assembly. This will vastly increase the programmability, functionality, and versatility of rationally designed DNA constructs.
PubMed: 36520622
DOI: 10.1002/anie.202213451
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (6.03 Å)
Structure validation

227561

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