8CPR
G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer
Summary for 8CPR
Entry DOI | 10.2210/pdb8cpr/pdb |
Descriptor | GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, ... (4 entities in total) |
Functional Keywords | kras, colorectal cancer, ras signalling, cancer stem cells, ras-driven metastasis, kras structure, kras mutations, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 19929.10 |
Authors | Moche, M.,Jungholm, O.,Strandback, E.,Ampah-Korsah, H.,Nyman, T.,Orwar, O. (deposition date: 2023-03-03, release date: 2024-06-12, Last modification date: 2024-09-11) |
Primary citation | Jungholm, O.,Trkulja, C.,Moche, M.,Srinivasa, S.P.,Christakopoulou, M.N.,Davidson, M.,Reymer, A.,Jardemark, K.,Fogaca, R.L.,Ashok, A.,Jeffries, G.,Ampah-Korsah, H.,Strandback, E.,Andrell, J.,Nyman, T.,Nouairia, G.,Orwar, O. Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody. Sci Rep, 14:19656-19656, 2024 Cited by PubMed: 39179604DOI: 10.1038/s41598-024-70217-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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