8CLB

Colchicine bound to tubulin (T2R-TTL) complex

Summary for 8CLB

Entry DOI	10.2210/pdb8clb/pdb
Descriptor	Tubulin alpha-1B chain, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Tubulin beta-2B chain, ... (11 entities in total)
Functional Keywords	drug-tubulin-complex cell cycle inhibition, cell cycle
Biological source	synthetic construct More
Total number of polymer chains	6
Total formula weight	249650.73
Authors	Wranik, M.,Kepa, M.W.,Bertrand, Q.,Weinert, T.,Steinmetz, M.,Standfuss, J. (deposition date: 2023-02-16, release date: 2023-12-13)
Primary citation	Wranik, M.,Kepa, M.W.,Beale, E.V.,James, D.,Bertrand, Q.,Weinert, T.,Furrer, A.,Glover, H.,Gashi, D.,Carrillo, M.,Kondo, Y.,Stipp, R.T.,Khusainov, G.,Nass, K.,Ozerov, D.,Cirelli, C.,Johnson, P.J.M.,Dworkowski, F.,Beale, J.H.,Stubbs, S.,Zamofing, T.,Schneider, M.,Krauskopf, K.,Gao, L.,Thorn-Seshold, O.,Bostedt, C.,Bacellar, C.,Steinmetz, M.O.,Milne, C.,Standfuss, J. A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers. Nat Commun, 14:7956-7956, 2023 Cited by PubMed: 38042952 DOI: 10.1038/s41467-023-43523-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation