8CI2
human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions
Summary for 8CI2
Entry DOI | 10.2210/pdb8ci2/pdb |
EMDB information | 16666 |
Descriptor | Neuronal acetylcholine receptor subunit alpha-7, Nanobody C4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | ion channel nanobody nicotinic acetylcholine receptor, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 272068.02 |
Authors | Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.-J. (deposition date: 2023-02-08, release date: 2023-10-11) |
Primary citation | Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.J. An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies. Nat Commun, 14:5964-5964, 2023 Cited by PubMed: 37749098DOI: 10.1038/s41467-023-41734-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.4 Å) |
Structure validation
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