8CI2

human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions

8CI2 の概要

• エントリーDOI: 10.2210/pdb8ci2/pdb
• EMDBエントリー: 16666
• 分子名称: Neuronal acetylcholine receptor subunit alpha-7, Nanobody C4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: ion channel nanobody nicotinic acetylcholine receptor, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 272068.02

構造登録者

Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.-J. (登録日: 2023-02-08, 公開日: 2023-10-11)

• 主引用文献: Prevost, M.S.,Barilone, N.,Dejean de la Batie, G.,Pons, S.,Ayme, G.,England, P.,Gielen, M.,Bontems, F.,Pehau-Arnaudet, G.,Maskos, U.,Lafaye, P.,Corringer, P.J.; An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies.; Nat Commun, 14:5964-5964, 2023; PubMed: 37749098; DOI: 10.1038/s41467-023-41734-4

実験手法

ELECTRON MICROSCOPY (4.4 Å)