8CGZ

tubulin-AB8939 complex

Summary for 8CGZ

• Entry DOI: 10.2210/pdb8cgz/pdb
• Descriptor: Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
• Functional Keywords: microtubule dynamics, inhibitor, cytoskeleton, cell division, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 5
• Total formula weight: 220209.10

Authors

Varela, P.F.,Gigant, B. (deposition date: 2023-02-06, release date: 2024-08-14)

• Primary citation: Humbert, M.,Letard, S.,Neves, M.,Siavoshian Jeay, S.,Goubard, A.,Casteran, N.,Rebuffet, E.,Hajem, B.,Gros, L.,Varela, P.F.,Gigant, B.,Verdier, P.,Castellano, R.,Colette, Y.,Vey, N.,Pez, D.,Benjahad, A.,Moussy, A.,Mansfield, C.,Dubreuil, P.; Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.527 Å)