8CE2

X-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetate

Summary for 8CE2

• Entry DOI: 10.2210/pdb8ce2/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, Rhodium, ... (5 entities in total)
• Functional Keywords: b-dna, dodecamer, dirhodium, interaction, dna
• Biological source: DNA molecule
• Total number of polymer chains: 2
• Total formula weight: 7592.35

Authors

Tito, G.,Troisi, R.,Ferraro, G.,Sica, F.,Merlino, A. (deposition date: 2023-02-01, release date: 2023-05-31, Last modification date: 2024-06-19)

Primary citation

Tito, G.,Troisi, R.,Ferraro, G.,Geri, A.,Massai, L.,Messori, L.,Sica, F.,Merlino, A.
Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry.
Dalton Trans, 52:6992-6996, 2023

PubMed Abstract: The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion.

PubMed: 37199244
DOI: 10.1039/d3dt00320e

Experimental method

X-RAY DIFFRACTION (1.24 Å)