8CE2

X-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetate

8CE2 の概要

• エントリーDOI: 10.2210/pdb8ce2/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, Rhodium, ... (5 entities in total)
• 機能のキーワード: b-dna, dodecamer, dirhodium, interaction, dna
• 由来する生物種: DNA molecule
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7592.35

構造登録者

Tito, G.,Troisi, R.,Ferraro, G.,Sica, F.,Merlino, A. (登録日: 2023-02-01, 公開日: 2023-05-31, 最終更新日: 2024-06-19)

主引用文献

Tito, G.,Troisi, R.,Ferraro, G.,Geri, A.,Massai, L.,Messori, L.,Sica, F.,Merlino, A.
Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry.
Dalton Trans, 52:6992-6996, 2023

PubMed Abstract: The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion.

PubMed: 37199244
DOI: 10.1039/d3dt00320e

実験手法

X-RAY DIFFRACTION (1.24 Å)