8CB1
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15
Summary for 8CB1
Entry DOI | 10.2210/pdb8cb1/pdb |
Descriptor | Lysosomal alpha-glucosidase (76 kDa), 1,2-ETHANEDIOL, (2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol, ... (13 entities in total) |
Functional Keywords | gaa, pompe disease, pharmacological chaperone, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 102042.72 |
Authors | Sulzenbacher, G.,Roig-Zamboni, V.,Overkleeft, H.,Artola, M. (deposition date: 2023-01-25, release date: 2023-09-13, Last modification date: 2023-11-15) |
Primary citation | van der Gracht, D.,Rowland, R.J.,Roig-Zamboni, V.,Ferraz, M.J.,Louwerse, M.,Geurink, P.P.,Aerts, J.M.F.G.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Artola, M. Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chem Sci, 14:9136-9144, 2023 Cited by PubMed: 37655021DOI: 10.1039/d3sc01021j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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