8CAA

Crystal structure of TEAD4 in complex with YTP-13

8CAA の概要

• エントリーDOI: 10.2210/pdb8caa/pdb
• 分子名称: Transcriptional enhancer factor TEF-3, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, ... (5 entities in total)
• 機能のキーワード: complex, inhibitor, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53271.06

構造登録者

Scheufler, C.,Kallen, J. (登録日: 2023-01-24, 公開日: 2023-04-12, 最終更新日: 2024-06-19)

• 主引用文献: Sellner, H.,Chapeau, E.,Furet, P.,Voegtle, M.,Salem, B.,Le Douget, M.,Bordas, V.,Groell, J.M.,Le Goff, A.L.,Rouzet, C.,Wietlisbach, T.,Zimmermann, T.,McKenna, J.,Brocklehurst, C.E.,Chene, P.,Wartmann, M.,Scheufler, C.,Kallen, J.,Williams, G.,Harlfinger, S.,Traebert, M.,Dumotier, B.M.,Schmelzle, T.,Soldermann, N.; Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.; Chemmedchem, 18:e202300051-e202300051, 2023; PubMed: 36988034; DOI: 10.1002/cmdc.202300051

実験手法

X-RAY DIFFRACTION (1.999 Å)