8C62

Crystal structure of cisplatin/B-DNA adduct

8C62 の概要

• エントリーDOI: 10.2210/pdb8c62/pdb
• 関連するPDBエントリー: 8C63 8C64
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), PLATINUM (II) ION (3 entities in total)
• 機能のキーワード: duplex, b-dna, cisplatin, anticancer agent, metallodrug, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8107.10

構造登録者

Troisi, R.,Tito, G.,Ferraro, G.,Sica, F.,Merlino, A. (登録日: 2023-01-11, 公開日: 2024-01-31, 最終更新日: 2024-02-28)

主引用文献

Troisi, R.,Tito, G.,Ferraro, G.,Sica, F.,Massai, L.,Geri, A.,Cirri, D.,Messori, L.,Merlino, A.
On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer.
Dalton Trans, 53:3476-3483, 2024

PubMed Abstract: The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticancer compounds is arsenoplatin-1 (AP-1) that contains an As(OH) fragment linked to a Pt(II) moiety derived from cisplatin. Crystallographic and spectrometric studies of AP-1 binding to a B-DNA double helix dodecamer are presented here, in comparison with cisplatin and transplatin. Results reveal that AP-1, cisplatin and transplatin react differently with the DNA model system. Notably, in the AP-1/DNA systems, the Pt-As bond can break down with time and As-containing fragments can be released. These results have implications for the understanding of the mechanism of action of arsenoplatins.

PubMed: 38270175
DOI: 10.1039/d3dt04302a

実験手法

X-RAY DIFFRACTION (2.31 Å)